Michail S Kukharsky Selected Research

latrepirdine (dimebon)

1/2021	A bioisostere of Dimebon/Latrepirdine delays the onset and slows the progression of pathology in FUS transgenic mice.
1/2013	Chronic administration of Dimebon does not ameliorate amyloid-β pathology in 5xFAD transgenic mice.
1/2013	Chronic administration of dimebon ameliorates pathology in TauP301S transgenic mice.

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Michail S Kukharsky Research Topics

Disease

4	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2021 - 04/2015
3	Neurodegenerative Diseases (Neurodegenerative Disease) 11/2021 - 01/2013
3	Alzheimer Disease (Alzheimer's Disease) 05/2016 - 01/2013
2	Sarcoma (Soft Tissue Sarcoma) 11/2019 - 01/2015
2	Amyloidosis 05/2016 - 01/2013
1	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 11/2021
1	TDP-43 Proteinopathies 11/2021
1	Frontotemporal Dementia (Semantic Dementia) 11/2021
1	Disease Progression 01/2021
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2021
1	Parkinson Disease (Parkinson's Disease) 01/2020
1	Teratoma (Teratoid Tumor) 07/2019
1	Proteostasis Deficiencies 01/2015
1	Tauopathies 01/2013
1	Pathologic Processes 01/2013

Drug/Important Bio-Agent (IBA)

3	Proteins (Proteins, Gene)FDA Link 11/2021 - 01/2014
3	latrepirdine (dimebon)IBA 01/2021 - 01/2013
2	RNA-Binding Protein FUSIBA 05/2020 - 11/2019
1	Long Noncoding RNAIBA 11/2021
1	human FUS proteinIBA 01/2021
1	Nuclear Proteins (Protein, Nuclear)IBA 01/2021
1	Retinaldehyde (Retinal)IBA 01/2021
1	Glutamic Acid (Glutamate)FDA Link 01/2021
1	SynucleinsIBA 01/2020
1	Amyloid (Amyloid Fibrils)IBA 05/2016
1	Trans-Activators (Trans-Acting Factor)IBA 04/2015
1	CalciumIBA 04/2015
1	RNA (Ribonucleic Acid)IBA 01/2015
1	RNA-Binding Proteins (RNA-Binding Protein)IBA 01/2015
1	Therapeutic UsesIBA 01/2014
1	Pharmaceutical PreparationsIBA 01/2013

Therapy/Procedure

2	Therapeutics 07/2019 - 01/2014
1	Intravenous Injections 05/2016
1	Intraperitoneal Injections 05/2016